Echinacea - Echinacea, sp.:
Appearance:
The flowers of this plant are typically purple, light
or dark toned depending on species. There
is a cone-shaped projection in the middle of the flower.
Echinacea purpurea: This is
the herb typically, but not exlusively, discussed. The plant grows to be tall and
stout; its petals droop back. The cone and petals are definitely purple, but the
pollen is yellow. The flowering plant is quite stunning.
Echinacea angustifola: This is a shorter plant, with
narrower leaves, and petals which are shorter and droop less. It is another
frequently-used species.
Other coneflowers - E. pallida,
E. gloriosa, E. stimulata, E. paradoxa: Descriptions of these species will be
written up as they become available, although E. paradoxa has yellow petals,
and E. pallida is often confused for E. angustifola.
Growing Info:
Coneflowers are herbaceous sun-loving perennials, and which are hardy given sufficient
water. They are a North American species, originating in the Great Plains/midwest regions of
the United States.
Culinary Uses:
We are not aware of any culinary uses for this herb.
Medicinal Uses in Folklore:
Native Americans from various tribes made use of the coneflowers in early times.
It has been used as a tonic, and as a treatment for arthritis. It is said to
help with urinary tract infections and other infections, as well as being a general
immune system builder. Applied topically, it may take the "bite" out of bites
and stings.
Scanning the Scientific Literature:
Echinacea purpurea or E. angustifolia
tend to be the most used of the
coneflowers. In part, this is due to the fact that some of the other echinaceas
have been little-studied. Bauer recommends labelling packaging as to which plant
(as well as which part of the plant -- leaf, root, or whole plant) is being used
in any treatment. Significant pharmacological effects are indicated from the
expressed juice of the upper parts of E. purpurea and for
alcoholic extracts of the roots of E. pallida, E. angustifolia
and E. purpurea. The activities are mainly directed towards the nonspecific
cellular immune system. Active constituents of even the known-active members
of this genus vary from species to species. (E. purpurea does not
contain echinacoside but has chichoric acid, whereas E. angustifola contains
the former but not the latter.) The components of E. pallida are variable
in their activity.
Saying that Echinacea is an immune stimulant doesn't really impart much information as
to which part of a complex immune system Echinacea affects. Much still waits to be
discovered about the role constituents of Echinacea extract play. It is known that
constituents of Echinacea act on phagocytic immune cells in the blood -- phagocytic
cells are ones which engulf/ingest bacteria and other pathogens in order to
destroy them. Macrophages are particularly known to be stimulated to such
activity. Water-soluable polysaccharides in both E. purpurea and
E. angustifolia have both been implicated in this effect, although there may
also be complex interactions ongoing with additional constituents of Echinacea.
One such polysaccharide is arabinogalactan. Another
water-soluable immunologically responsive component of E. angustifolia
and E. pallida, but which is not a polysaccharide, is echinacoside.
At any rate, purified polysaccharides from Echinacea purpurea may well
stimulate macrophages and monocytes to produce Il-1, TNFα, and IL-6, and may
increase the proliferation of macrophages in bone marrow and spleen,
to be released to the body. There is evidence that these polysaccharides may
provide a level of protection against at least certain systemic infections.
Echinacea exhibits anti-inflammatory activities, and has been studied especially in
E. angustifolia root extracts. Certain polyunsaturated alkamides obtained
from Echinacea angustifolia were able to inhibit cyclooxygenase and
5-lipoxygenase activity in vitro, important for helping to decrease
inflammations.
There are indications that Echinacea extracts, in conjunction with other
cancer therapies, may have anti-carcinogenic effects, due to their mechanisms of
action upon the immune system.
E. purpurea extracts may also promote the effective functioning of
many fat-soluble vitamins (including E and A), given that the
vitamins are replenished in the diet.
Echinacea purpurea seems to be virtually non-toxic and non-mutagenic. In some
rare cases, allergies to these plants are possible.
Other Info:
These plants are in the family Asteraceae. The original Latin name for
E. purpurea was Rudbeckia purpurea; although this designation
went out of favor in the mid 1800's, one
can still find reference to the plant under this name.
Other common names, besides purple coneflower, for this plant are red sunflower,
comb flower, Indian head, black sampson, cock up hat, Missouri snakeroot, or Kansas
snakeroot.
References:
- Hobbs, Christopher. Echinacea: The Immune Herb.
- Tyler, V. E. The Honest Herbal.
- Bauer R.
[Echinacea drugs--effects and active ingredients]. [Review] [German]
Zeitschrift fur Arztliche Fortbildung. 90(2):111-5, 1996 Apr.
- Mengs U. Clare CB. Poiley JA.
Toxicity of Echinacea purpurea. Acute, subacute and genotoxicity studies.
Arzneimittel-Forschung. 41(10):1076-81, 1991 Oct.
- Tragni E. Tubaro A. Melis S. Galli CL.
Evidence from two classic irritation tests for an anti-inflammatory action
of a natural extract, Echinacina B. Food & Chemical Toxicology.
23(2):317-9, 1985 Feb.
- Tubaro A. Tragni E. Del Negro P. Galli CL. Della Loggia R.
Anti-inflammatory activity of a polysaccharidic fraction of Echinacea
angustifolia. Journal of Pharmacy & Pharmacology. 39(7):567-9, 1987 Jul.
- Tragni E. Galli CL. Tubaro A. Del Negro P. Della Loggia R.
Anti-inflammatory activity of Echinacea angustifolia fractions separated
on the basis of molecular weight. Pharmacological Research Communications.
20 Suppl 5:87-90, 1988 Dec.
- Muller-Jakic B. Breu W. Probstle A. Redl K. Greger H. Bauer R.
In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from
Echinacea and Achillea species. Planta Medica. 60(1):37-40, 1994 Feb.
- Lersch C. Zeuner M. Bauer A. Siebenrock K. Hart R. Wagner F. Fink U.
Dancygier H. Classen M.
Stimulation of the immune response in outpatients with hepatocellular
carcinomas by low doses of cyclophosphamide (LDCY), echinacea purpurea
extracts (Echinacin) and thymostimulin. Archiv fur Geschwulstforschung.
60(5):379-83, 1990.
- Lersch C. Zeuner M. Bauer A. Siemens M. Hart R. Drescher M. Fink U.
Dancygier H. Classen M.
Nonspecific immunostimulation with low doses of cyclophosphamide (LDCY),
thymostimulin, and Echinacea purpurea extracts (echinacin) in patients
with far advanced colorectal cancers: preliminary results. Cancer Investigation.
10(5):343-8, 1992.
- Paranich AV. Pocherniaeva VF. Dubinskaia GM. Mishchenko VP. Mironova
NG. Gugalo VP. Nazarets VV.
[Effect of supposed radioprotectors on oxidation-reduction of vitamin E in
the tissues of irradiated rats]. [Russian]
Radiatsionnaia Biologiia, Radioecologiia. 33(5):653-7, 1993 Sep-Oct.
- Wildfeuer A. Mayerhofer D.
[The effects of plant preparations on cellular functions in body defense].
[German] Arzneimittel-Forschung. 44(3):361-6, 1994 Mar.
- Bukovsky M. Kostalova D. Magnusova R. Vaverkova S.
[Testing for immunomodulating effects of ethanol-water extracts of the
above-ground parts of the plants Echinaceae (Moench) and Rudbeckia L.].
[Slovak] Ceskoslovenska Farmacie. 42(5):228-31, 1993 Oct.
- Steinmuller C. Roesler J. Grottrup E. Franke G. Wagner H.
Lohmann-Matthes ML.
Polysaccharides isolated from plant cell cultures of Echinacea purpurea
enhance the resistance of immunosuppressed mice against systemic
infections with Candida albicans and Listeria monocytogenes.
International Journal of Immunopharmacology. 15(5):605-14, 1993 Jul.
- Schumacher A. Friedberg KD.
[The effect of Echinacea angustifolia on non-specific cellular immunity in
the mouse]. [German] Arzneimittel-Forschung. 41(2):141-7, 1991 Feb.
- Roesler J. Steinmuller C. Kiderlen A. Emmendorffer A. Wagner H.
Lohmann-Matthes ML.
Application of purified polysaccharides from cell cultures of the plant
Echinacea purpurea to mice mediates protection against systemic infections
with Listeria monocytogenes and Candida albicans.
International Journal of Immunopharmacology. 13(1):27-37, 1991.
- Roesler J. Emmendorffer A. Steinmuller C. Luettig B. Wagner H.
Lohmann-Matthes ML.
Application of purified polysaccharides from cell cultures of the plant
Echinacea purpurea to test subjects mediates activation of the phagocyte
system. International Journal of Immunopharmacology. 13(7):931-41, 1991.
- Luettig B. Steinmuller C. Gifford GE. Wagner H. Lohmann-Matthes ML.
Macrophage activation by the polysaccharide arabinogalactan isolated from
plant cell cultures of Echinacea purpurea. Journal of the National Cancer
Institute. 81(9):669-75, 1989 May 3.
- Stimpel M. Proksch A. Wagner H. Lohmann-Matthes ML.
Macrophage activation and induction of macrophage cytotoxicity by purified
polysaccharide fractions from the plant Echinacea purpurea. Infection &
Immunity. 46(3):845-9, 1984 Dec.
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Last Updated: March 7, 1999.