Anti-tumor effects of ginger extract have been seen in mouse experimental models. With regards to liver function, aryl hydrocarbon hydroxylase activity was significantly elevated with ginger oil treatment. This activity seems to be implicated with activation and detoxication of foreign biotic compounds, including chemical carcinogens and mutagens. Components of ginger also appear to be mild superoxide scavengers, an activity with implications for its anti-carcinogenic effects.
Ginger oil suppressed arthritis in a rat model of this disease. In a study of human clients, powdered ginger helped many but not all arthritis patients by relieving pain and swelling. All the patients with muscular discomfort experience pain relief. No adverse effects were noticed during the period under study. Established medical drugs from industry all show mild or serious side effects. One mechanism by which ginger may show effective behavior may be related to inhibition of prostaglandin and leukotriene biosynthesis. Gingerols and diarylhepatanoids have been identified as active anti-prostaglandin compounds. Another constituent, (6)-shogaol, may act as an analgesic by inhibiting the release of the immunoreactive substance P.
While some preparations of ginger can increase blood coagulation time, by interfering with the performance of blood platelets, therapeutic doses of dried ginger do not seem to have an effect.
Dried ginger rhizomes exhibit antirhinoviral activity in the plaque reduction test. Several sesquiterpenes, especially beta-sesquiphellandrene, were isolated with this effect. (The rhinovirus is the virus associated with the common cold; thus ginger apparently can act against the virus which causes the common cold.
Contact dermatitis is possible with ginger.
[Effect of different preparations of ginger on blood coagulation time in mice]. [Chinese] Chung-Kuo Chung Yao Tsa Chih - China Journal of Chinese Materia Medica. 18(3):147-9, 190, 1993 Mar.
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