Monoamine oxidase is a necessary enzyme produced in the body which
breaks down certain kinds of amines which can be harmful if they are allowed
to accumulate. A monoamine oxidase inhibitor will inhibit the ability of
this enzyme to do its job. An accumulation of tyramine is especially
dangerous. Tyramine is made from the protein tyrosine in the gut. If one
uses a monoamine oxidase inhibitor, it is important to stay away from
tyrosine-containing foods (such as red wine, cocoa, aged cheeses, and some
pickled foods). Symptoms of tyramine buildup may include headache, stiff
neck, cardiovascular problems, and, in unchecked and severe cases, death.
MAO inhibitors may intensify or prolong the effects of other drugs (CNS
depressants, narcotic analgesics, dibenzazepine antidepressants, anticholinergics)
by interfering with their metabolism and eventual breakdown. Don't combine
with sedatives, antihistamines, alcohol, tranquilizers or narcotics, due
to the possibility of a severe blood pressure drop through the decrease in
clearing ability (metabolism) of the other drugs.